Ovarian cancer CA-125 blood test: does it work? -

September 2013. The most popular screening test for ovarian cancer, the CA-125 test, by itself is not a good screening tool for ovarian cancer. When used alone on women with no symptoms or previous history of ovarian cancer, it leads to many false positives. Among women who have already been treated for ovarian cancer once, it doesn’t seem to improve length of quality of life.